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| 1095 |
| | | Pope Urban II preaches the first crusade, urging the Christians of Europe to march east to recover Jerusalem from the Muslims | |
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| 1147 |
| | | The second crusade is led east by two kings, Louis VII of France and Conrad III of Germany | |
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| 1157 |
| | | A Russian prince, Andrei Bogolyubski, makes his capital east of Moscow at Vladimir, where he builds a cathedral and several churches | |
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| 1190 |
| | | A year after succeeding to the throne of England, Richard I sets off east as one of the leaders of the third crusade | |
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| c. 1200 |
| | | The samurai provide military support for the shogun, in a system similar to feudalism at this same period in Europe | |
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| 1271 |
| | | Marco Polo, aged seventeen, sets off from Venice on his journey to the east | |
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| 1295 |
| | | Marco Polo is back in Venice after an absence of 25 years in the east | |
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| 1493 |
| | | Pope Alexander VI draws a line through the Atlantic, dividing new discoveries between Spain (west) and Portugal (east) | |
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| 1577 |
| | | Francis Drake sails from Plymouth, heading west for the Pacific and the East Indies | |
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| 1594 |
| | | Willem Barents sets off on the first of his three expeditions to find a passage to the east through the waters north of Russia | |
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